suppression by virus of host ISG15-protein conjugation
Term Information
Accession
GO:0039579
Name
suppression by virus of host ISG15-protein conjugation
Ontology
biological_process
Synonyms
suppression by virus of host ISG15 activity
Alternate IDs
None
Definition
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.
Source:PMID:18604270,
PMID:11157743