Term Information

Accession
GO:0039560
Name
disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity
Ontology
biological_process
Synonyms
inhibition of host IRF9 by virus, inhibition of host interferon regulatory factor-9 by virus, suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity, suppression by virus of host IRF9 activity, suppression by virus of host interferon regulatory factor 9 activity
Alternate IDs
None
Definition
Any process in which a virus interferes with a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes. Source: PMID:19109390, PMID:10388655
Comment
This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
History
See term history for GO:0039560 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity (GO:0039560)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity [is_a relation] is_a  disruption by virus of host JAK-STAT cascade (GO:0039514)
disruption by virus of host JAK-STAT cascade via inhibition of host IRF9 activity [is_a relation] is_a  suppression by virus of host innate immune response (GO:0039503)

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