Term Information

Accession
GO:0039548
Name
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Ontology
biological_process
Synonyms
inhibition of IRF3-dependent antiviral response, inhibition of host IRF3 by virus, suppression by virus of host IRF3 activity, suppression by virus of host interferon regulatory factor 3
Alternate IDs
None
Definition
Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. Source: PMID:21632562
Comment
This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
History
See term history for GO:0039548 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity (GO:0039548)
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suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity [is_a relation] is_a  suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)

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