Term Information

Accession
GO:0039540
Name
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity
Ontology
biological_process
Synonyms
inhibition of host DDX58/RIG-I by virus, suppression by virus of host RIG-I signalling pathway, inhibition by virus of host DDX58 activity, inhibition by virus of host RIG-I, inhibition by virus of host RIG-I signaling, suppression by virus of host DDX58 signaling pathway, suppression by virus of host RIG-I activity, suppression by virus of host RIG-I signaling pathway
Alternate IDs
GO:0039538
Definition
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. Source: PMID:19454348, PMID:26138103
Comment
This term is for annotation of viral proteins that counteract the host anti-viral innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I).
History
See term history for GO:0039540 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity (GO:0039540)
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suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity [is_a relation] is_a  suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)

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