Term Information

Accession
GO:0038084
Name
vascular endothelial growth factor signaling pathway
Ontology
biological_process
Synonyms
VEGF signaling, VEGF-activated signaling pathway, vascular endothelial growth factor signalling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Source: GOC:signaling, PMID:17470632
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
History
See term history for GO:0038084 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of vascular endothelial growth factor signaling pathway (GO:0038084)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
vascular endothelial growth factor signaling pathway [BFO:0000050 relation] BFO:0000050  cellular response to vascular endothelial growth factor stimulus (GO:0035924)
vascular endothelial growth factor signaling pathway [is_a relation] is_a  transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
Children of vascular endothelial growth factor signaling pathway (GO:0038084)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of vascular endothelial growth factor signaling pathway (GO:1900748) [RO:0002213 relation] RO:0002213  vascular endothelial growth factor signaling pathway
VEGF-activated neuropilin signaling pathway (GO:0038190) [is_a relation] is_a  vascular endothelial growth factor signaling pathway
VEGF-activated platelet-derived growth factor receptor signaling pathway (GO:0038086) [is_a relation] is_a  vascular endothelial growth factor signaling pathway
regulation of vascular endothelial growth factor signaling pathway (GO:1900746) [RO:0002211 relation] RO:0002211  vascular endothelial growth factor signaling pathway
vascular endothelial growth factor receptor activity (GO:0005021) [BFO:0000050 relation] BFO:0000050  vascular endothelial growth factor signaling pathway
negative regulation of vascular endothelial growth factor signaling pathway (GO:1900747) [RO:0002212 relation] RO:0002212  vascular endothelial growth factor signaling pathway
positive regulation of cell migration by vascular endothelial growth factor signaling pathway (GO:0038089) [is_a relation] is_a  vascular endothelial growth factor signaling pathway
None.