Mum2, Ime4, and Slz1 complex, WMM complex, METTL3-METTL14-WTAP methyltransferase complex, MIS complex, m(6)A writer complex, m6A methyltransferase complex
Alternate IDs
None
Definition
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).
Source:PMID:29547716,
GOC:sp,
PMID:24407421,
GOC:dgf,
PMID:29507755,
PMID:29535189,
PMID:24316715,
PMID:22685417