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mediator complex assembly

Term Information

Accession
GO:0036034
Name
mediator complex assembly
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:17641689, GOC:yaf
Comment
None
History
See term history for GO:0036034 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of mediator complex assembly (GO:0036034)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mediator complex assembly [is_a relation] is_a  protein-containing complex assembly (GO:0065003)
Children of mediator complex assembly (GO:0036034)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of mediator complex assembly (GO:2001177) [RO:0002212 relation] RO:0002212  mediator complex assembly
positive regulation of mediator complex assembly (GO:2001178) [RO:0002213 relation] RO:0002213  mediator complex assembly
regulation of mediator complex assembly (GO:2001176) [RO:0002211 relation] RO:0002211  mediator complex assembly
None.