Term Information

Accession
GO:0035582
Name
sequestering of BMP in extracellular matrix
Ontology
biological_process
Synonyms
BMP sequestration in the ECM, negative regulation of BMP signaling pathway by extracellular sequestering of BMP, negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP, negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
Alternate IDs
None
Definition
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. Source: GOC:BHF, PMID:20855508
Comment
Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
History
See term history for GO:0035582 at QuickGO
Subset
None
Feedback
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Parents of sequestering of BMP in extracellular matrix (GO:0035582)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
sequestering of BMP in extracellular matrix [is_a relation] is_a  negative regulation of BMP signaling pathway (GO:0030514)
sequestering of BMP in extracellular matrix [is_a relation] is_a  sequestering of extracellular ligand from receptor (GO:0035581)
sequestering of BMP in extracellular matrix [is_a relation] is_a  maintenance of protein location in extracellular region (GO:0071694)

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