Planteome: Term Details for "pre-B cell receptor complex" (GO:0035369)

Accession: GO:0035369
Name: pre-B cell receptor complex
Ontology: cellular_component
Synonyms: pre-BCR
Alternate IDs: None
Definition: An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. Source: ISBN:0781765196, PMID:16464608, GOC:add, PMID:17306522
Comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
History: See term history for GO:0035369 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to pre-B cell receptor complex.; Link to all direct and indirect annotations to pre-B cell receptor complex.; Link to all direct and indirect annotations download (limited to first 10,000) for pre-B cell receptor complex.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

subject	relation	object
pre-B cell receptor complex	is_a	membrane protein complex (GO:0098796)

This term has no children.

pre-B cell receptor complex