Planteome: Term Details for "amyloid-beta formation" (GO:0034205)

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Term Information

Accession: GO:0034205
Name: amyloid-beta formation
Ontology: biological_process
Synonyms: beta-amyloid formation, beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein
Alternate IDs: None
Definition: The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). Source: GOC:mah
Comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
History: See term history for GO:0034205 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to amyloid-beta formation.; Link to all direct and indirect annotations to amyloid-beta formation.; Link to all direct and indirect annotations download (limited to first 10,000) for amyloid-beta formation.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0043170 macromolecule metabolic process
GO:0006807 nitrogen compound metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0043603 amide metabolic process
GO:0019538 protein metabolic process
GO:0042982 amyloid precursor protein metabolic process
GO:0006518 peptide metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0050435 amyloid-beta metabolic process
GO:0034205 amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902004 positive regulation of amyloid-beta formation
GO:1902003 regulation of amyloid-beta formation

Parents of amyloid-beta formation (GO:0034205)

subject	relation	object
amyloid-beta formation	is_a	amyloid-beta metabolic process (GO:0050435)
amyloid-beta formation	is_a	amyloid precursor protein catabolic process (GO:0042987)

Children of amyloid-beta formation (GO:0034205)

subject	relation	object
negative regulation of amyloid-beta formation (GO:1902430)	RO:0002212	amyloid-beta formation
positive regulation of amyloid-beta formation (GO:1902004)	RO:0002213	amyloid-beta formation
regulation of amyloid-beta formation (GO:1902003)	RO:0002211	amyloid-beta formation

amyloid-beta formation

Term Information

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Parents of amyloid-beta formation (GO:0034205)

Children of amyloid-beta formation (GO:0034205)

None.