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DNA recombinase mediator complex

Term Information

Accession
GO:0033061
Name
DNA recombinase mediator complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange. Source: PMID:12912992, GOC:vw, InterPro:IPR003488, GOC:elh, GOC:mah, PMID:32414915
Comment
Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly.
History
See term history for GO:0033061 at QuickGO
Subset
goslim_pir
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of DNA recombinase mediator complex (GO:0033061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA recombinase mediator complex [is_a relation] is_a  protein-containing complex (GO:0032991)
Children of DNA recombinase mediator complex (GO:0033061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Rad51C-XRCC3 complex (GO:0033065) [is_a relation] is_a  DNA recombinase mediator complex
Swi5-Sfr1 complex (GO:0032798) [is_a relation] is_a  DNA recombinase mediator complex
Rad51B-Rad51C complex (GO:0033066) [is_a relation] is_a  DNA recombinase mediator complex
XRCC2-RAD51D complex (GO:0033064) [is_a relation] is_a  DNA recombinase mediator complex
Rad51B-Rad51C-Rad51D-XRCC2 complex (GO:0033063) [is_a relation] is_a  DNA recombinase mediator complex
None.