Planteome: Term Details for "neuromuscular junction" (GO:0031594)

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Term Information

Accession: GO:0031594
Name: neuromuscular junction
Ontology: cellular_component
Synonyms: NMJ, motor endplate
Alternate IDs: None
Definition: The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. Source: GOC:nln
Comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
History: See term history for GO:0031594 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to neuromuscular junction.; Link to all direct and indirect annotations to neuromuscular junction.; Link to all direct and indirect annotations download (limited to first 10,000) for neuromuscular junction.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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GO:0005575 cellular_component
GO:0110165 cellular anatomical entity
GO:0030054 cell junction
GO:0045202 synapse
GO:0031594 neuromuscular junction
GO:0098520 excitatory neuromuscular junction
GO:0098521 inhibitory neuromuscular junction
GO:0098523 neuromuscular junction of myotube
GO:0098527 neuromuscular junction of somatic muscle
GO:0098975 postsynapse of neuromuscular junction

Parents of neuromuscular junction (GO:0031594)

subject	relation	object
neuromuscular junction	is_a	synapse (GO:0045202)

Children of neuromuscular junction (GO:0031594)

subject	relation	object
neuromuscular junction of myotube (GO:0098523)	is_a	neuromuscular junction
neuromuscular junction of somatic muscle (GO:0098527)	is_a	neuromuscular junction
excitatory neuromuscular junction (GO:0098520)	is_a	neuromuscular junction
postsynapse of neuromuscular junction (GO:0098975)	BFO:0000050	neuromuscular junction
inhibitory neuromuscular junction (GO:0098521)	is_a	neuromuscular junction

NIF_Subcellular: sao1124888485
Wikipedia: Neuromuscular_junction