protein arginine N5-methylase activity, protein-arginine N5-methyltransferase activity, protein-arginine delta-N-methyltransferase activity, type IV PRMT activity, type IV protein arginine methyltransferase activity, S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)
Alternate IDs
None
Definition
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine.
Source:EC:2.1.1.322,
PMID:9873020,
PMID:11856739
Comment
This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are R67 of the ribosomal protein L12.