Planteome logo

RNA polymerase II general transcription initiation factor activity

Term Information

Accession
GO:0016251
Name
RNA polymerase II general transcription initiation factor activity
Ontology
molecular_function
Synonyms
GTF2 activity, basal RNA polymerase II transcription factor activity, general RNA polymerase II transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly, sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly, transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
Alternate IDs
GO:0003703, GO:0000983, GO:0001075
Definition
A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. Source: PMID:25693126, GOC:txnOH-2018, PMID:10384286, PMID:23442138, PMID:10747032
Comment
General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
History
See term history for GO:0016251 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of RNA polymerase II general transcription initiation factor activity (GO:0016251)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase II general transcription initiation factor activity [BFO:0000050 relation] BFO:0000050  transcription by RNA polymerase II (GO:0006366)
RNA polymerase II general transcription initiation factor activity [is_a relation] is_a  general transcription initiation factor activity (GO:0140223)

This term has no children.

None.