Planteome logo

IkappaB kinase complex

Term Information

Accession
GO:0008385
Name
IkappaB kinase complex
Ontology
cellular_component
Synonyms
IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Alternate IDs
None
Definition
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:bf, GOC:ma, PMID:20300203, PMID:12055104
Comment
None
History
See term history for GO:0008385 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of IkappaB kinase complex (GO:0008385)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)
IkappaB kinase complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)

This term has no children.

None.