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IkappaB kinase complex

Term Information

Accession
GO:0008385
Name
IkappaB kinase complex
Ontology
cellular_component
Synonyms
IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Alternate IDs
None
Definition
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:bf, GOC:ma, PMID:20300203, PMID:12055104
Comment
None
History
See term history for GO:0008385 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of IkappaB kinase complex (GO:0008385)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)
IkappaB kinase complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)

This term has no children.

None.