Planteome: Term Details for "glutamate decarboxylation to succinate" (GO:0006540)

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Term Information

Accession: GO:0006540
Name: glutamate decarboxylation to succinate
Ontology: biological_process
Synonyms: 4-aminobutyrate shunt, GABA shunt, degradation of glutamate to succinate through GABA, gamma-aminobutyrate shunt, glutamate degradation via 4-aminobutyrate, glutamate degradation via GABA
Alternate IDs: None
Definition: The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. Source: PMID:12740438
Comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
History: See term history for GO:0006540 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to glutamate decarboxylation to succinate.; Link to all direct and indirect annotations to glutamate decarboxylation to succinate.; Link to all direct and indirect annotations download (limited to first 10,000) for glutamate decarboxylation to succinate.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
BFO:0000015 process
GO:0009056 catabolic process
GO:0044237 cellular metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0006082 organic acid metabolic process
GO:0071704 organic substance metabolic process
GO:0044281 small molecule metabolic process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0044248 cellular catabolic process
GO:1901575 organic substance catabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0043436 oxoacid metabolic process
GO:0044238 primary metabolic process
GO:0044282 small molecule catabolic process
GO:1901605 alpha-amino acid metabolic process
GO:0046395 carboxylic acid catabolic process
GO:0016054 organic acid catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1901606 alpha-amino acid catabolic process
GO:0043603 amide metabolic process
GO:0009063 amino acid catabolic process
GO:0043648 dicarboxylic acid metabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0043649 dicarboxylic acid catabolic process
GO:0006536 glutamate metabolic process
GO:0009065 glutamine family amino acid catabolic process
GO:0006538 glutamate catabolic process
GO:0006540 glutamate decarboxylation to succinate
GO:0036242 glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity
GO:0019549 glutamate catabolic process to succinate via succinate semialdehyde

Parents of glutamate decarboxylation to succinate (GO:0006540)

subject	relation	object
glutamate decarboxylation to succinate	BFO:0000051	4-aminobutyrate transaminase activity (GO:0003867)
glutamate decarboxylation to succinate	is_a	glutamate catabolic process (GO:0006538)
glutamate decarboxylation to succinate	BFO:0000051	glutamate decarboxylase activity (GO:0004351)

Children of glutamate decarboxylation to succinate (GO:0006540)

subject	relation	object
glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity (GO:0036242)	is_a	glutamate decarboxylation to succinate
glutamate catabolic process to succinate via succinate semialdehyde (GO:0019549)	is_a	glutamate decarboxylation to succinate

MetaCyc: PWY-4321; PWY3O-210; GLUDEG-I-PWY