Term Information

Accession
GO:0005085
Name
guanyl-nucleotide exchange factor activity
Ontology
molecular_function
Synonyms
GDP-dissociation stimulator activity, GDS, GEF, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor, GNRP
Alternate IDs
GO:0019839, GO:0016219, GO:0008433
Definition
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Source: GOC:mah, GOC:kd
Comment
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
History
See term history for GO:0005085 at QuickGO
Subset
goslim_chembl
goslim_drosophila
goslim_yeast
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of guanyl-nucleotide exchange factor activity (GO:0005085)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
guanyl-nucleotide exchange factor activity [is_a relation] is_a  GTPase binding (GO:0051020)
guanyl-nucleotide exchange factor activity [is_a relation] is_a  molecular function regulator (GO:0098772)
Children of guanyl-nucleotide exchange factor activity (GO:0005085)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of guanyl-nucleotide exchange factor activity (GO:1905099) [RO:0002213 relation] RO:0002213  guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity (GO:0005088) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
regulation of guanyl-nucleotide exchange factor activity (GO:1905097) [RO:0002211 relation] RO:0002211  guanyl-nucleotide exchange factor activity
cAMP-dependent guanyl-nucleotide exchange factor activity (GO:0017132) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
ARF guanyl-nucleotide exchange factor activity (GO:0005086) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity (GO:0005090) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
negative regulation of guanyl-nucleotide exchange factor activity (GO:1905098) [RO:0002212 relation] RO:0002212  guanyl-nucleotide exchange factor activity