Planteome: Term Details for "guanyl-nucleotide exchange factor activity" (GO:0005085)

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Term Information

Accession: GO:0005085
Name: guanyl-nucleotide exchange factor activity
Ontology: molecular_function
Synonyms: GDP-dissociation stimulator activity, GDS, GEF, Rho guanine nucleotide exchange factor, RhoGEF, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor, ARF guanyl-nucleotide exchange factor activity, GNRP, Rab guanyl-nucleotide exchange factor activity, Rac guanyl-nucleotide exchange factor activity, Ral guanyl-nucleotide exchange factor activity, Ran guanyl-nucleotide exchange factor activity, Rap guanyl-nucleotide exchange factor activity, Ras guanyl-nucleotide exchange factor activity, Rho guanyl-nucleotide exchange factor activity, Sar guanyl-nucleotide exchange factor activity, cAMP-dependent guanyl-nucleotide exchange factor activity
Alternate IDs: GO:0017132, GO:0008321, GO:0005087, GO:0016220, GO:0017034, GO:0005088, GO:0005086, GO:0005090, GO:0030676, GO:0019839, GO:0016219, GO:0017112, GO:0008433, GO:0005089
Definition: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. Source: PMID:27218782, GOC:mah, PMID:23303910, GOC:kd
Comment: None
History: See term history for GO:0005085 at QuickGO
Subset: goslim_chembl; goslim_drosophila; goslim_yeast
Related: Link to all annotated objects annotated to guanyl-nucleotide exchange factor activity.; Link to all direct and indirect annotations to guanyl-nucleotide exchange factor activity.; Link to all direct and indirect annotations download (limited to first 10,000) for guanyl-nucleotide exchange factor activity.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0003674 molecular_function
GO:0098772 molecular function regulator activity
GO:0030234 enzyme regulator activity
GO:0060589 nucleoside-triphosphatase regulator activity
GO:0030695 GTPase regulator activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1905099 positive regulation of guanyl-nucleotide exchange factor activity
GO:1905097 regulation of guanyl-nucleotide exchange factor activity

Parents of guanyl-nucleotide exchange factor activity (GO:0005085)

subject	relation	object
guanyl-nucleotide exchange factor activity	is_a	GTPase regulator activity (GO:0030695)

Children of guanyl-nucleotide exchange factor activity (GO:0005085)

subject	relation	object
positive regulation of guanyl-nucleotide exchange factor activity (GO:1905099)	RO:0002213	guanyl-nucleotide exchange factor activity
negative regulation of guanyl-nucleotide exchange factor activity (GO:1905098)	RO:0002212	guanyl-nucleotide exchange factor activity
regulation of guanyl-nucleotide exchange factor activity (GO:1905097)	RO:0002211	guanyl-nucleotide exchange factor activity

Reactome: R-HSA-416588; R-HSA-5654600; R-HSA-6811418; R-HSA-9640167; R-HSA-9693111; R-HSA-9666428; R-HSA-9018747; R-HSA-5218850; R-HSA-177945; R-HSA-187746; R-HSA-2029467; R-HSA-9026891; R-HSA-9666430; R-HSA-392195; R-HSA-8876190; R-HSA-389348; R-HSA-8876191; R-HSA-2485180; R-HSA-392870; R-HSA-109807; R-HSA-203977; R-HSA-8876193; R-HSA-442291; R-HSA-8982640; R-HSA-9664991; R-HSA-170979; R-HSA-8876615; R-HSA-8877308; R-HSA-5218839; R-HSA-419166; R-HSA-8876616; R-HSA-9017491; R-HSA-399938; R-HSA-8877311; R-HSA-8876188; R-HSA-1433415; R-HSA-177938; R-HSA-6811414; R-HSA-9033292; R-HSA-3928651; R-HSA-114544; R-HSA-2029451; R-HSA-442732; R-HSA-8982637; R-HSA-825631; R-HSA-4093336; R-HSA-9660824; R-HSA-5617816; R-HSA-5654426; R-HSA-9032067; R-HSA-9680385; R-HSA-5218829; R-HSA-939265; R-HSA-9036301; R-HSA-8877813; R-HSA-9013435; R-HSA-9013159; R-HSA-2424476; R-HSA-5655241; R-HSA-169904; R-HSA-171026; R-HSA-2029445; R-HSA-2424477; R-HSA-8876454; R-HSA-380073; R-HSA-3928642; R-HSA-392054; R-HSA-9639286; R-HSA-5654392; R-HSA-8851827; R-HSA-418850; R-HSA-9665707; R-HSA-3928592; R-HSA-428535; R-HSA-418579; R-HSA-442273; R-HSA-1250498; R-HSA-9013143; R-HSA-5654413; R-HSA-5637806; R-HSA-9013023; R-HSA-194518; R-HSA-5637808; R-HSA-9665700; R-HSA-9634418; R-HSA-8876837; R-HSA-8875591; R-HSA-9703441; R-HSA-5654663; R-HSA-1250383; R-HSA-8980691; R-HSA-418856; R-HSA-3928632; R-HSA-1433471; R-HSA-3928633; R-HSA-399995; R-HSA-442314; R-HSA-5694409; R-HSA-354173; R-HSA-5654402; R-HSA-9029158; R-HSA-9751201; R-HSA-5654647; R-HSA-8877998; R-HSA-9624845; R-HSA-2179407; R-HSA-9695853; R-HSA-9018825; R-HSA-8851899; R-HSA-8877760; R-HSA-3928628; R-HSA-5623521; R-HSA-5655347; R-HSA-205039; R-HSA-420883; R-HSA-5686071; R-HSA-751029; R-HSA-749453; R-HSA-416530; R-HSA-9670436; R-HSA-428750; R-HSA-9032798; R-HSA-9665408; R-HSA-9018817; R-HSA-9619803; R-HSA-5655326; R-HSA-8875568; R-HSA-5623508; R-HSA-9665009; R-HSA-9665404; R-HSA-210977; R-HSA-8877475; R-HSA-8850041; R-HSA-350769; R-HSA-3928612; R-HSA-428917; R-HSA-1306972; R-HSA-9018804; R-HSA-379044; R-HSA-8877612; R-HSA-1225957; R-HSA-1168636; R-HSA-9672163; R-HSA-9018768; R-HSA-8875318; R-HSA-5672965; R-HSA-8851877; R-HSA-156913; R-HSA-6807868; R-HSA-9607304; R-HSA-8875320; R-HSA-2730840; R-HSA-9672170; R-HSA-186834; R-HSA-9014296; R-HSA-379048; R-HSA-9013109; R-HSA-445064; R-HSA-389350; R-HSA-8848618; R-HSA-6811429; R-HSA-5686318; R-HSA-8964604; R-HSA-9014433; R-HSA-5654618; R-HSA-3965444; R-HSA-1225951; R-HSA-5655277; R-HSA-8877451; R-HSA-1250463; R-HSA-180687; R-HSA-109817