Term Information

Accession
GO:0004972
Name
NMDA glutamate receptor activity
Ontology
molecular_function
Synonyms
N-methyl-D-aspartate selective glutamate receptor activity, NMDA receptor
Alternate IDs
None
Definition
An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. Source: PMID:10049997, GOC:mah
Comment
The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product.
History
See term history for GO:0004972 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of NMDA glutamate receptor activity (GO:0004972)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
NMDA glutamate receptor activity [is_a relation] is_a  ionotropic glutamate receptor activity (GO:0004970)
NMDA glutamate receptor activity [is_a relation] is_a  voltage-gated monoatomic ion channel activity (GO:0005244)
NMDA glutamate receptor activity [is_a relation] is_a  inorganic cation transmembrane transporter activity (GO:0022890)
Children of NMDA glutamate receptor activity (GO:0004972)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of NMDA receptor activity (GO:2000310) [RO:0002211 relation] RO:0002211  NMDA glutamate receptor activity
negative regulation of NMDA glutamate receptor activity (GO:1904782) [RO:0002212 relation] RO:0002212  NMDA glutamate receptor activity
positive regulation of NMDA glutamate receptor activity (GO:1904783) [RO:0002213 relation] RO:0002213  NMDA glutamate receptor activity
Wikipedia
NMDA_receptor