Term Information

Accession
GO:0004879
Name
nuclear receptor activity
Ontology
molecular_function
Synonyms
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-dependent nuclear receptor activity, ligand-dependent transcription factor activity, 1,25-(OH)2D3 receptor activity, 9-cis retinoic acid receptor activity, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding, RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding, RXR, androgen receptor activity, calcitriol receptor activity, ecdysteroid hormone receptor activity, estrogen nuclear receptor activity, glucocorticoid receptor activity, juvenile hormone receptor activity, nuclear hormone receptor, retinoic acid receptor activity, retinoid-X receptor activity, thyroid hormone receptor activity, vitamin A receptor activity, vitamin D receptor activity, vitamin D3 receptor activity
Alternate IDs
GO:0038052, GO:0038050, GO:0038051, GO:0004886, GO:0004887, GO:0004884, GO:0004882, GO:0004880, GO:0003708, GO:0008434
Definition
A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. Source: PMID:23457262, GOC:txnOH-2018
Comment
Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.
History
See term history for GO:0004879 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of nuclear receptor activity (GO:0004879)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nuclear receptor activity [BFO:0000050 relation] BFO:0000050  intracellular receptor signaling pathway (GO:0030522)
nuclear receptor activity [is_a relation] is_a  DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)
nuclear receptor activity [is_a relation] is_a  signaling receptor activity (GO:0038023)
nuclear receptor activity [is_a relation] is_a  ligand-activated transcription factor activity (GO:0098531)
Children of nuclear receptor activity (GO:0004879)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of androgen receptor activity (GO:2000825) [RO:0002213 relation] RO:0002213  nuclear receptor activity
None.