Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate.
Source:EC:4.2.1.70,
RHEA:18337
Comment
Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine.