GGTase-II activity, GGTaseII activity, Rab-protein geranylgeranyltransferase activity, RabGGTase activity, geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity, protein geranylgeranyltransferase type II activity, type II protein geranyl-geranyltransferase activity
Alternate IDs
None
Definition
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
Source:PMID:8621375,
GOC:mah,
EC:2.5.1.60