Planteome: Term Details for "methylenetetrahydrofolate reductase (NAD(P)H) activity" (GO:0004489)

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Term Information

Accession: GO:0004489
Name: methylenetetrahydrofolate reductase (NAD(P)H) activity
Ontology: molecular_function
Synonyms: 5,10-methylenetetrahydrofolate reductase (FADH) activity, 5,10-methylenetetrahydrofolate reductase (FADH2) activity, 5,10-CH(2)-H(4)folate reductase activity, 5,10-CH2-H4folate reductase activity, 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity, 5,10-methylenetetrahydrofolate reductase (NADPH) activity, 5,10-methylenetetrahydropteroylglutamate reductase activity, 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity, 5-methyltetrahydrofolate:NAD oxidoreductase activity, 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity, 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity, 5-methyltetrahydrofolate:NAD+ oxidoreductase activity, 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity, 5-methyltetrahydrofolate:NADP+ oxidoreductase activity, MetF, N5,10-methylenetetrahydrofolate reductase activity, N5,N10-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity, methylenetetrahydrofolate reductase (NADPH(2)) activity, methylenetetrahydrofolate reductase (NADPH2), methylenetetrahydrofolate reductase [NAD(P)H], 5,10-methylenetetrahydrofolate reductase activity, 5,10-methylenetetrahydrofolic acid reductase activity, MTHFR activity, N(5),N(10)-methylenetetrahydrofolate reductase activity, N(5,10)-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate reductase activity, methylenetetrahydrofolic acid reductase activity
Alternate IDs: GO:0008702
Definition: Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. Source: PMID:26872964, EC:1.5.1.20
Comment: None
History: See term history for GO:0004489 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to methylenetetrahydrofolate reductase (NAD(P)H) activity.; Link to all direct and indirect annotations to methylenetetrahydrofolate reductase (NAD(P)H) activity.; Link to all direct and indirect annotations download (limited to first 10,000) for methylenetetrahydrofolate reductase (NAD(P)H) activity.
Feedback: Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0106312 methylenetetrahydrofolate reductase NADH activity
GO:0106313 methylenetetrahydrofolate reductase NADPH activity
GO:1903869 negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:1903870 positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:1903868 regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity

Parents of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)

subject	relation	object
methylenetetrahydrofolate reductase (NAD(P)H) activity	is_a	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)

Children of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)

subject	relation	object
methylenetetrahydrofolate reductase NADH activity (GO:0106312)	is_a	methylenetetrahydrofolate reductase (NAD(P)H) activity
methylenetetrahydrofolate reductase NADPH activity (GO:0106313)	is_a	methylenetetrahydrofolate reductase (NAD(P)H) activity
positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903870)	RO:0002213	methylenetetrahydrofolate reductase (NAD(P)H) activity
regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903868)	RO:0002211	methylenetetrahydrofolate reductase (NAD(P)H) activity
negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903869)	RO:0002212	methylenetetrahydrofolate reductase (NAD(P)H) activity

EC: 1.5.1.20
KEGG_REACTION: R01224; R07168
MetaCyc: 1.5.1.20-RXN
Reactome: R-HSA-200676