Term Information

Accession
GO:0004473
Name
malate dehydrogenase (decarboxylating) (NADP+) activity
Ontology
molecular_function
Synonyms
'malic' enzyme, (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating), L-malate:NADP oxidoreductase activity, NADP-linked decarboxylating malic enzyme, NADP-malic enzyme activity, NADP-specific malate dehydrogenase activity, NADP-specific malic enzyme, malate dehydrogenase (NADP, decarboxylating), malate dehydrogenase (decarboxylating, NADP)
Alternate IDs
None
Definition
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Source: EC:1.1.1.40
Comment
For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
History
See term history for GO:0004473 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
malate dehydrogenase (decarboxylating) (NADP+) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)
malate dehydrogenase (decarboxylating) (NADP+) activity [is_a relation] is_a  malic enzyme activity (GO:0004470)
Children of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903218) [RO:0002211 relation] RO:0002211  malate dehydrogenase (decarboxylating) (NADP+) activity
negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903219) [RO:0002212 relation] RO:0002212  malate dehydrogenase (decarboxylating) (NADP+) activity
positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity (GO:1903220) [RO:0002213 relation] RO:0002213  malate dehydrogenase (decarboxylating) (NADP+) activity
EC
1.1.1.40
KEGG_REACTION
R00216
MetaCyc
MALIC-NADP-RXN
Reactome
R-HSA-9012349
R-HSA-9012036
RHEA
18253