Term Information

Accession
GO:0004471
Name
malate dehydrogenase (decarboxylating) (NAD+) activity
Ontology
molecular_function
Synonyms
malate dehydrogenase (oxaloacetate-decarboxylating) activity, 'malic' enzyme, (S)-malate:NAD+ oxidoreductase (decarboxylating), (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating), NAD-linked malic enzyme, NAD-specific malic enzyme, malate dehydrogenase (decarboxylating) activity, NAD-malic enzyme activity
Alternate IDs
GO:0004472, GO:0016619
Definition
Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Source: EC:1.1.1.39, EC:1.1.1.38
Comment
For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
History
See term history for GO:0004471 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
malate dehydrogenase (decarboxylating) (NAD+) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)
malate dehydrogenase (decarboxylating) (NAD+) activity [is_a relation] is_a  malic enzyme activity (GO:0004470)

This term has no children.

EC
1.1.1.39
1.1.1.38
KEGG_REACTION
R00214
MetaCyc
1.1.1.39-RXN
MALIC-NAD-RXN
Reactome
R-HSA-9012268
RHEA
12653