Term Information

Accession
GO:0002353
Name
plasma kallikrein-kinin cascade
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. Source: PMID:11842287, PMID:14501145, GOC:add, ISBN:0721601871
Comment
None
History
See term history for GO:0002353 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of plasma kallikrein-kinin cascade (GO:0002353)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
plasma kallikrein-kinin cascade [is_a relation] is_a  kinin cascade (GO:0002254)
Children of plasma kallikrein-kinin cascade (GO:0002353)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of plasma kallikrein-kinin cascade (GO:0002549) [RO:0002212 relation] RO:0002212  plasma kallikrein-kinin cascade
positive regulation of plasma kallikrein-kinin cascade (GO:0002550) [RO:0002213 relation] RO:0002213  plasma kallikrein-kinin cascade
regulation of plasma kallikrein-kinin cascade (GO:0002529) [RO:0002211 relation] RO:0002211  plasma kallikrein-kinin cascade
Factor XII activation (GO:0002542) [BFO:0000050 relation] BFO:0000050  plasma kallikrein-kinin cascade
None.