5-HT1 receptor activity, serotonin receptor activity, coupled via Gi/o
Alternate IDs
None
Definition
Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.
Source:PMID:18571247,
GOC:mah