Term Information

Accession
GO:0000386
Name
second spliceosomal transesterification activity
Ontology
molecular_function
Synonyms
lariat formation, 5'-splice site cleavage, 3'-splice site cleavage, exon ligation
Alternate IDs
None
Definition
Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. Source: GOC:krc, PMID:19239890, ISBN:0879695897
Comment
None
History
See term history for GO:0000386 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of second spliceosomal transesterification activity (GO:0000386)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
second spliceosomal transesterification activity [is_a relation] is_a  catalytic activity, acting on RNA (GO:0140098)
second spliceosomal transesterification activity [BFO:0000050 relation] BFO:0000050  RNA splicing, via transesterification reactions (GO:0000375)

This term has no children.

Reactome
R-HSA-9770236