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EC 5.99.1.2 (DNA topoisomerase) inhibitor

Term Information

Accession
CHEBI:50276
Name
EC 5.99.1.2 (DNA topoisomerase) inhibitor
Ontology
Synonyms
DNA topoisomerase inhibitor, DNA topoisomerase inhibitors, EC 5.99.1.2 (DNA topoisomerase) inhibitors, EC 5.99.1.2 (topoisomerase I) inhibitor, EC 5.99.1.2 (topoisomerase I) inhibitors, EC 5.99.1.2 inhibitor, EC 5.99.1.2 inhibitors, topoisomerase I (EC 5.99.1.2) inhibitor, topoisomerase I (EC 5.99.1.2) inhibitors, topoisomerase I inhibitor, topoisomerase I inhibitors, type I DNA topoisomerase inhibitor, type I DNA topoisomerase inhibitors
Alternate IDs
None
Definition
A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. [source: unknown]
Comment
None
Subset
None
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Parents of EC 5.99.1.2 (DNA topoisomerase) inhibitor (CHEBI:50276)
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EC 5.99.1.2 (DNA topoisomerase) inhibitor [is_a relation] is_a  topoisomerase inhibitor (CHEBI:70727)

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