Term Information

Accession
GO:1990909
Name
Wnt signalosome
Ontology
cellular_component
Synonyms
LRP5/6 signalosome, Wnt signalosome complex, Wnt-LRP5/6 signalosome, LRP6 signalosome
Alternate IDs
None
Definition
A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. Source: PMID:22899650, GOC:PARL, PMID:25336320, GOC:bf
Comment
Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
History
See term history for GO:1990909 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of Wnt signalosome (GO:1990909)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Wnt signalosome [is_a relation] is_a  protein-containing complex (GO:0032991)
Wnt signalosome [BFO:0000051 relation] BFO:0000051  Wnt-Frizzled-LRP5/6 complex (GO:1990851)

This term has no children.

None.