Term Information

Accession
GO:1990666
Name
PCSK9-LDLR complex
Ontology
cellular_component
Synonyms
PCSK9.LDLR complex, PCSK9/LDL-R complex, PCSK9:low-density lipoprotein receptor complex, PCSK9:EGF-A complex
Alternate IDs
None
Definition
A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. Source: PMID:18250299, GOC:BHF, GOC:nc, PMID:24440079
Comment
None
History
See term history for GO:1990666 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of PCSK9-LDLR complex (GO:1990666)
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PCSK9-LDLR complex [is_a relation] is_a  protein-containing complex (GO:0032991)

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None.