Term Information

Accession
GO:1990332
Name
Ire1 complex
Ontology
cellular_component
Synonyms
IRE1 dimer, ERN1 complex
Alternate IDs
None
Definition
A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. Source: PMID:18191223, GOC:bf, PMID:25437541, GOC:bhm
Comment
An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
History
See term history for GO:1990332 at QuickGO
Subset
None
Feedback
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Parents of Ire1 complex (GO:1990332)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Ire1 complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)
Ire1 complex [is_a relation] is_a  endoplasmic reticulum part (GO:0044432)
Ire1 complex [is_a relation] is_a  membrane protein complex (GO:0098796)
Ire1 complex [BFO:0000050 relation] BFO:0000050  endoplasmic reticulum membrane (GO:0005789)
Ire1 complex [is_a relation] is_a  endoribonuclease complex (GO:1902555)

This term has no children.

IntAct
EBI-8872439