Term Information

Accession
GO:1990231
Name
STING complex
Ontology
cellular_component
Synonyms
stimulator of interferon genes complex
Alternate IDs
None
Definition
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. Source: PMID:23910378, PMID:23706668, PMID:22705373, GOC:bhm
Comment
None
History
See term history for GO:1990231 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of STING complex (GO:1990231)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
STING complex [is_a relation] is_a  membrane protein complex (GO:0098796)
STING complex [BFO:0000050 relation] BFO:0000050  cytoplasmic vesicle membrane (GO:0030659)

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None.