Term Information

Accession
GO:0140223
Name
general transcription initiation factor activity
Ontology
molecular_function
Synonyms
GTF activity, basal transcription factor activity, general transcription factor activity
Alternate IDs
None
Definition
An activity that contributes to transcription start site selection and transcription initiation. Source: GOC:txnOH-2018
Comment
General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
History
See term history for GO:0140223 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of general transcription initiation factor activity (GO:0140223)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
general transcription initiation factor activity [is_a relation] is_a  transcription regulator activity (GO:0140110)
general transcription initiation factor activity [BFO:0000050 relation] BFO:0000050  transcription, DNA-templated (GO:0006351)
Children of general transcription initiation factor activity (GO:0140223)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase I general transcription initiation factor activity (GO:0001181) [is_a relation] is_a  general transcription initiation factor activity
RNA polymerase II general transcription initiation factor activity (GO:0016251) [is_a relation] is_a  general transcription initiation factor activity
RNA polymerase III general transcription initiation factor activity (GO:0000995) [is_a relation] is_a  general transcription initiation factor activity
None.