Term Information

Accession
GO:0045857
Name
negative regulation of molecular function, epigenetic
Ontology
biological_process
Synonyms
down regulation of protein activity, epigenetic, down-regulation of protein activity, epigenetic, downregulation of protein activity, epigenetic, negative regulation of protein activity, epigenetic, inhibition of protein activity, epigenetic
Alternate IDs
None
Definition
Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. Source: GOC:go_curators, GOC:dph, GOC:tb
Comment
None
History
See term history for GO:0045857 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of negative regulation of molecular function, epigenetic (GO:0045857)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of molecular function, epigenetic [is_a relation] is_a  negative regulation of molecular function (GO:0044092)
negative regulation of molecular function, epigenetic [is_a relation] is_a  regulation of molecular function, epigenetic (GO:0040030)

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