Term Information

Accession
GO:0040030
Name
regulation of molecular function, epigenetic
Ontology
biological_process
Synonyms
regulation of protein activity, epigenetic
Alternate IDs
None
Definition
Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. Source: PMID:11447696, PMID:11782551, GOC:ems, PMID:10611975, GOC:dph, GOC:tb, PMID:11050225, PMID:11685242
Comment
None
History
See term history for GO:0040030 at QuickGO
Subset
None
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of regulation of molecular function, epigenetic (GO:0040030)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of molecular function, epigenetic [is_a relation] is_a  regulation of molecular function (GO:0065009)
Children of regulation of molecular function, epigenetic (GO:0040030)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of molecular function, epigenetic (GO:0045858) [is_a relation] is_a  regulation of molecular function, epigenetic
negative regulation of molecular function, epigenetic (GO:0045857) [is_a relation] is_a  regulation of molecular function, epigenetic
None.