Term Information

Accession
GO:0034098
Name
VCP-NPL4-UFD1 AAA ATPase complex
Ontology
cellular_component
Synonyms
p97-Ufd1-Npl4 complex, Cdc48p-Npl4p-Ufd1p AAA ATPase complex
Alternate IDs
None
Definition
A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). Source: PMID:11813000, PMID:16179952
Comment
None
History
See term history for GO:0034098 at QuickGO
Subset
None
Feedback
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Parents of VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
VCP-NPL4-UFD1 AAA ATPase complex [BFO:0000051 relation] BFO:0000051  UFD1-NPL4 complex (GO:0036501)
VCP-NPL4-UFD1 AAA ATPase complex [is_a relation] is_a  endoplasmic reticulum part (GO:0044432)
VCP-NPL4-UFD1 AAA ATPase complex [is_a relation] is_a  membrane protein complex (GO:0098796)
VCP-NPL4-UFD1 AAA ATPase complex [BFO:0000050 relation] BFO:0000050  endoplasmic reticulum membrane (GO:0005789)

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None.