Term Information

Accession
GO:0030122
Name
AP-2 adaptor complex
Ontology
cellular_component
Synonyms
HA2, HA2 clathrin adaptor
Alternate IDs
None
Definition
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). Source: PMID:22022230, PMID:10611976, GOC:mah, PMID:21097499, PMID:24322426
Comment
None
History
See term history for GO:0030122 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of AP-2 adaptor complex (GO:0030122)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
AP-2 adaptor complex [BFO:0000050 relation] BFO:0000050  clathrin coat of coated pit (GO:0030132)
AP-2 adaptor complex [is_a relation] is_a  clathrin adaptor complex (GO:0030131)
AP-2 adaptor complex [is_a relation] is_a  plasma membrane protein complex (GO:0098797)
AP-2 adaptor complex [BFO:0000050 relation] BFO:0000050  clathrin coat of endocytic vesicle (GO:0030128)

This term has no children.

None.