Term Information

Accession
GO:0006956
Name
complement activation
Ontology
biological_process
Synonyms
complement cascade, complement response, complement activity
Alternate IDs
None
Definition
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. Source: GOC:mtg_15nov05, ISBN:0781735149, GO_REF:0000022, GOC:add
Comment
This term was improved by GO_REF:0000022. It was moved.
History
See term history for GO:0006956 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of complement activation (GO:0006956)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
complement activation [is_a relation] is_a  activation of immune response (GO:0002253)
complement activation [is_a relation] is_a  humoral immune response (GO:0006959)
complement activation [is_a relation] is_a  protein activation cascade (GO:0072376)
complement activation [is_a relation] is_a  immune effector process (GO:0002252)
Children of complement activation (GO:0006956)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of complement activation (GO:0030449) [RO:0002211 relation] RO:0002211  complement activation
activation of membrane attack complex (GO:0001905) [is_a relation] is_a  complement activation
complement activation, lectin pathway (GO:0001867) [is_a relation] is_a  complement activation
complement activation, alternative pathway (GO:0006957) [is_a relation] is_a  complement activation
complement activation, classical pathway (GO:0006958) [is_a relation] is_a  complement activation
negative regulation of complement activation (GO:0045916) [RO:0002212 relation] RO:0002212  complement activation
complement-dependent cytotoxicity (GO:0097278) [BFO:0000051 relation] BFO:0000051  complement activation
positive regulation of complement activation (GO:0045917) [RO:0002213 relation] RO:0002213  complement activation