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store-operated calcium entry

Term Information

Accession
GO:0002115
Name
store-operated calcium entry
Ontology
biological_process
Synonyms
SOCE, capacitative calcium entry, store-operated calcium import, calcium ion import
Alternate IDs
None
Definition
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. Source: PMID:17956991, PMID:11120592, GOC:hjd
Comment
SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
History
See term history for GO:0002115 at QuickGO
Subset
None
Feedback
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of store-operated calcium entry (GO:0002115)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
store-operated calcium entry [is_a relation] is_a  calcium ion transport (GO:0006816)
Children of store-operated calcium entry (GO:0002115)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of store-operated calcium entry (GO:2001256) [RO:0002211 relation] RO:0002211  store-operated calcium entry
negative regulation of store-operated calcium entry (GO:0106128) [RO:0002212 relation] RO:0002212  store-operated calcium entry
positive regulation of store-operated calcium entry (GO:0106129) [RO:0002213 relation] RO:0002213  store-operated calcium entry
None.