Term Information

Accession
GO:0001204
Name
bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Ontology
molecular_function
Synonyms
metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
Alternate IDs
None
Definition
Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist. Source: PMID:22084422, PMID:2674688, GOC:txnOH, PMID:12829265, PMID:12829264
Comment
This term is intended for sequence specific DNA-binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
History
See term history for GO:0001204 at QuickGO
Subset
None
Feedback
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Parents of bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding (GO:0001204)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding [is_a relation] is_a  transcription factor activity, metal ion regulated sequence-specific DNA binding (GO:0001199)
bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding [is_a relation] is_a  bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding (GO:0001130)
Children of bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding (GO:0001204)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding (GO:0001218) [is_a relation] is_a  bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding (GO:0001215) [is_a relation] is_a  bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
None.